Julien Pirrello

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Julien Pirrello


Actual Research Project:  

My research project concerns hormonal control of fruit ripening. I am particularly interested in transcriptional control of this process.

Scientific carrier




Fruit ripening, transcriptional regulation, ethylene





  • Shin JH, Mila I, Liu M, Rodrigues MA, Vernoux T, Pirrello J, Bouzayen M. The RIN-regulated Small Auxin-Up RNA SAUR69 is involved in the unripe-to-ripe phase transition of tomato fruit via enhancement of the sensitivity to ethylene. New Phytol. 2019 Apr;222(2):820-836. doi: 10.1111/nph.15618.


  • Klay I, Gouia S, Liu M, Mila I, Khoudi H, Bernadac A, Bouzayen M, Pirrello J. Ethylene Response Factors (ERF) are differentially regulated by different abiotic stress types in tomato plants. Plant Sci. 2018 Sep;274:137-145. doi: 10.1016/j.plantsci.2018.05.023.
  • Djemal R, Mila I, Bouzayen M, Pirrello J, Khoudi H. Molecular cloning and characterization of novel WIN1/SHN1 ethylene responsive transcription factor HvSHN1 in barley (Hordeum vulgare L.). J Plant Physiol. 2018 Sep;228:39-46. doi: 10.1016/j.jplph.2018.04.019.
  • Deng H, Pirrello J, Chen Y, Li N, Zhu S, Chirinos X, Bouzayen M, Liu Y, Liu M. A novel tomato F-box protein, SlEBF3, is involved in tuning ethylene signaling during plant development and climacteric fruit ripening. Plant J. 2018 May 23. doi: 10.1111/tpj.13976.
  • Liu M, Chen Y, Chen Y, Shin JH, Mila I, Audran C, Zouine M, Pirrello J, Bouzayen M. The tomato Ethylene Response Factor Sl-ERF.B3 integrates ethylene and auxin signaling via direct regulation of Sl-Aux/IAA27.New Phytol. 2018 Jul;219(2):631-640. doi: 10.1111/nph.15165.2017.
  • Pirrello J, Deluche C, Frangne N, Gévaudant F, Maza E, Djari A, Bourge M, Renaudin JP, Brown S, Bowler C, Zouine M, Chevalier C, Gonzalez N. Transcriptome profiling of sorted endoreduplicated nuclei from tomato fruits: how the global shift in expression ascribed to DNA ploidy influences RNA-Seq data normalization and interpretation. Plant J. 2018 Jan;93(2):387-398. doi: 10.1111/tpj.13783. Erratum in: Plant J. 2018 Dec;96(6):1317.


  • Zouine M, Maza E, Djari A, Lauvernier M, Frasse P, Smouni A, Pirrello J, Bouzayen M. TomExpress, a unified tomato RNA-Seq platform for visualization of expression data, clustering and correlation networks. Plant J. 2017 Nov;92(4):727-735. doi: 10.1111/tpj.13711. Epub 2017 Oct 25.


  • Chaabouni S, Pirrello J, Liu M, El-Sharkawy I, Roustan JP, Bouzayen M. Identification and functional characterization of two HOOKLESS genes in Tomato (Solanum lycopersicum). J Plant Physiol. 2016 Aug 1;200:76-81. doi: 10.1016/j.jplph.2016.05.017

  • Liu M, Lima Gomes B, Mila I, Purgatto E, Peres LE, Frasse P, Maza E, Zouine M, Roustan JP, Bouzayen M, Pirrello J. Comprehensive profiling of Ethylene Response Factors expression identifies ripening-associated ERF genes and their link to key regulators of fruit ripening in tomato (Solanum lycopersicum). Plant Physiol. 2016 Jan 6.   



  • Liu M, Pirrello J, Chervin C, Roustan JP, Bouzayen M. Ethylene Control of Fruit Ripening: Revisiting the Complex Network of Transcriptional Regulation. Plant Physiol. 2015 Dec;169(4):2380-90.  
  • Makhloufi E, Yousfi FE, Pirrello J, Bernadac A, Ghorbel A, Bouzayen M. TdERF1, an ethylene response factor associated with dehydration responses in durum wheat (Triticum turgidum L. subsp. durum). Plant Signal Behav. 2015;10(10).  
  • Putranto RA, Herlinawati E, Rio M, Leclercq J, Piyatrakul P, Gohet E, Sanier C, Oktavia F, Pirrello J, Kuswanhadi, Montoro P. Involvement of Ethylene in the Latex Metabolism and Tapping Panel Dryness of Hevea brasiliensis. Int J Mol Sci. 2015 Aug 4;16(8):17885-908.  
  • Putranto RA, Duan C, Kuswanhadi, Chaidamsari T, Rio M, Piyatrakul P, Herlinawati E, Pirrello J, Dessailly F, Leclercq J, Bonnot F, Tang C, Hu S, Montoro P. Ethylene Response Factors Are Controlled by Multiple Harvesting Stresses in Hevea brasiliensis. PLoS One. 2015 Apr 23;10(4).  


  • Pirrello J, Leclercq J, Dessailly F, Rio M, Piyatrakul P, Kuswanhadi K, Tang C, Montoro P. Transcriptional and post-transcriptional regulation of the jasmonate signalling pathway in response to abiotic and harvesting stress in Hevea brasiliensis. BMC Plant Biol. 2014 Dec 2;14:341.   

  • Klay I, Pirrello J, Riahi L, Bernadac A, Cherif A, Bouzayen M, Bouzid S. Ethylene response factor Sl-ERF.B.3 is responsive to abiotic stresses and mediates salt and cold stress response regulation in tomato. ScientificWorldJournal. 2014:167681. 

  • Piyatrakul P, Yang M, Putranto RA, Pirrello J, Dessailly F, Hu S, Summo M, Theeravatanasuk K, Leclercq J, Kuswanhadi, Montoro P. Sequence and expression analyses of ethylene response factors highly expressed in latex cells from Hevea brasiliensis. PLoS One. 2014 Jun 27;9(6).   

  • Liu M, Diretto G, Pirrello J, Roustan JP, Li Z, Giuliano G, Regad F, Bouzayen M. The chimeric repressor version of an Ethylene Response Factor (ERF) family member, Sl-ERF.B3, shows contrasting effects on tomato fruit ripening. New Phytol. 2014 Jul;203(1):206-18.    
  • Pirrello J, Bourdon M, Cheniclet C, Bourge M, Brown SC, Renaudin JP, Frangne N, Chevalier C. How fruit developmental biology makes use of flow cytometry approaches. Cytometry A. 2014 Feb;85(2):115-25. 
  • Chevalier C, Bourdon M, Pirrello J, Cheniclet C, Gévaudant F, Frangne N. Endoreduplication and fruit growth in tomato: evidence in favour of the karyoplasmic ratio theory. J Exp Bot. 2014 Jun;65(10):2731-46.   



  • Liu M, Pirrello J, Kesari R, Mila I, Roustan JP, Li Z, Latché A, Pech JC, Bouzayen M, Regad F. A dominant repressor version of the tomato Sl-ERF.B3 gene confers ethylene hypersensitivity via feedback regulation of ethylene signaling and response components. Plant J. 2013 Nov;76(3):406-19. 
  • Duan C, Argout X, Gébelin V, Summo M, Dufayard JF, Leclercq J, Kuswanhadi, Piyatrakul P, Pirrello J, Rio M, Champion A, Montoro P. Identification of the Hevea brasiliensis AP2/ERF superfamily by RNA sequencing. BMC Genomics. 2013 Jan 16;14:30.  
  • Bouaziz D, Pirrello J, Charfeddine M, Hammami A, Jbir R, Dhieb A, Bouzayen M, Gargouri-Bouzid R. Overexpression of StDREB1 transcription factor increases tolerance to salt in transgenic potato plants. Mol Biotechnol. 2013 Jul;54(3):803-17. 



  • Pirrello J, Prasad BC, Zhang W, Chen K, Mila I, Zouine M, Latché A, Pech JC, Ohme-Takagi M, Regad F, Bouzayen M. Functional analysis and binding affinity of tomato ethylene response factors provide insight on the molecular bases of plant differential responses to ethylene. BMC Plant Biol. 2012 Oct 11;12:190.  

  • Bourdon M, Pirrello J, Cheniclet C, Coriton O, Bourge M, Brown S, Moïse A, Peypelut M, Rouyère V, Renaudin JP, Chevalier C, Frangne N. Evidence for karyoplasmic homeostasis during endoreduplication and a ploidy-dependent increase in gene transcription during tomato fruit growth. Development. 2012 Oct;139(20):3817-26.  

  • Bouaziz D, Pirrello J, Ben Amor H, Hammami A, Charfeddine M, Dhieb A, Bouzayen M, Gargouri-Bouzid R. Ectopic expression of dehydration responsive element binding proteins (StDREB2) confers higher tolerance to salt stress in potato. Plant Physiol Biochem. 2012 Nov;60:98-108.  



  • Bourdon M, Coriton O, Pirrello J, Cheniclet C, Brown SC, Poujol C, Chevalier C, Renaudin JP, Frangne N. In planta quantification of endoreduplication using fluorescent in situ hybridization (FISH). Plant J. 2011 Jun;66(6):1089-99.   
  • Yang Y, Wu Y, Pirrello J, Regad F, Bouzayen M, Deng W, Li Z. Silencing Sl-EBF1 and Sl-EBF2 expression causes constitutive ethylene response phenotype, accelerated plant senescence, and fruit ripening in tomato. J Exp Bot. 2010 Mar;61(3):697-708. 



  • Marchive C, Mzid R, Deluc L, Barrieu F, Pirrello J, Gauthier A, Corio-Costet MF, Regad F, Cailleteau B, Hamdi S, Lauvergeat V. Isolation and characterization of a Vitis vinifera transcription factor, VvWRKY1, and its effect on responses to fungal pathogens in transgenic tobacco plants. J Exp Bot. 2007;58(8):1999-2010. 



  • Pirrello J, Jaimes-Miranda F, Sanchez-Ballesta MT, Tournier B, Khalil-Ahmad Q, Regad F, Latché A, Pech JC, Bouzayen M. Sl-ERF2, a tomato ethylene response factor involved in ethylene response and seed germination. Plant Cell Physiol.2006 Sep;47(9):1195-205.